Zhong Yang, He Jia-Wei, Huang Chun-Xia, Lai Heng-Zhou, Li Xue-Ke, Zheng Chuan, Fu Xi, You Feng-Ming, Ma Qiong
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610072, China.
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610072, China.
J Transl Med. 2025 Mar 14;23(1):326. doi: 10.1186/s12967-025-06326-4.
Early diagnosis of lung cancer (LC) is challenging, treatment options are limited, and treatment resistance leads to poor prognosis and management in most patients. The Wnt/β-catenin signaling pathway plays a vital role in the occurrence, progression, and therapeutic response of LC. Recent studies indicate that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) function as epigenetic regulators that can promote or inhibit Wnt/β-catenin signaling by interacting with Wnt proteins, receptors, signaling transducers, and transcriptional effectors, thereby affecting LC cell proliferation, metastasis, invasion, and treatment resistance. Deepening our understanding of the regulatory network between ncRNAs and the Wnt/β-catenin signaling pathway will help overcome the limitations of current LC diagnosis and treatment methods. This article comprehensively reviews the regulatory mechanisms related to the functions of ncRNAs and the Wnt/β-catenin pathway in LC, examining their potential as diagnostic and prognostic biomarkers and therapeutic targets, aiming to offer new promising perspectives for LC diagnosis and treatment.
肺癌（LC）的早期诊断具有挑战性，治疗选择有限，且多数患者会出现治疗耐药，导致预后不良和治疗管理困难。Wnt/β-连环蛋白信号通路在肺癌的发生、发展及治疗反应中起着至关重要的作用。近期研究表明，非编码RNA（ncRNAs），包括微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），作为表观遗传调控因子，可通过与Wnt蛋白、受体、信号转导分子及转录效应因子相互作用，促进或抑制Wnt/β-连环蛋白信号通路，从而影响肺癌细胞的增殖、转移、侵袭及治疗耐药性。深入了解ncRNAs与Wnt/β-连环蛋白信号通路之间的调控网络，将有助于克服当前肺癌诊断和治疗方法的局限性。本文全面综述了ncRNAs功能与肺癌中Wnt/β-连环蛋白通路相关的调控机制，探讨其作为诊断和预后生物标志物及治疗靶点的潜力，旨在为肺癌的诊断和治疗提供新的有前景的视角。
