Farkas Gary J, Gorgey Ashraf S, Dolbow David R, Berg Arthur S, Gater David R
a Department of Physical Medicine and Rehabilitation , Penn State College of Medicine , Hershey , Pennsylvania , USA.
b Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VA Medical Center , Richmond , Virginia , USA.
J Spinal Cord Med. 2019 Jul;42(4):430-436. doi: 10.1080/10790268.2018.1436125. Epub 2018 Feb 21.
We aimed to examine the influence of sex on the distribution of adipose tissue, as well as proinflammatory adipokine and cardiometabolic profiles, in chronic motor complete spinal cord injury (SCI). Cross-sectional and correlational study. Academic rehabilitation hospital. Forty-seven individuals with chronic motor complete SCI classified according to sex (males: age 44.0 ± 10.9 y, body mass index (BMI) 27.2 ± 5.8, level of injury (LOI) C4 - L1; females: 42.0 ± 13.5 y, BMI 27.8 ± 6.6, LOI C4 - T11). Not applicable. Visceral (VAT), subcutaneous (SAT), and total trunk (TTAT) adipose tissue volumes were assessed utilizing magnetic resonance imaging and a VAT:SAT ratio was calculated. Proinflammatory adipokines (tumor neurosis factor-α, interleukin-6, plasminogen activator inhibitor-1, thrombin-activatable fibrinolysis inhibitor, and high sensitivity c-reactive protein) and cardiovascular, carbohydrate, and lipid profiles were evaluated according to standard techniques. VAT and VAT:SAT ratio were significantly greater in male participates with SCI (P ≤ 0.002), while SAT volume was significantly greater in female participants with SCI (P = 0.001). No difference was noted in TTAT between groups (P = 0.341). Male participants with SCI demonstrated lower high-density lipoprotein-cholesterol (HDLC) profiles and an elevated total cholesterol to HDLC ratio (P ≤ 0.003) compared with females. No other significant differences were found between groups concerning cardiometabolic profiles or proinflammatory adipokines; however, males exhibited poorer profiles overall. Proinflammatory adipokines significantly correlated with adipose tissue depots by sex (P < 0.05). The results show that sex influences the distribution of adipose tissue, and may influence proinflammatory and cardiometabolic profiles following SCI. The findings of this study highlight the need for further research with dietary modification and exercise to decrease health risks.
我们旨在研究性别对慢性运动完全性脊髓损伤（SCI）患者脂肪组织分布、促炎脂肪因子及心脏代谢指标的影响。横断面相关性研究。学术康复医院。47例慢性运动完全性SCI患者，根据性别分类（男性：年龄44.0±10.9岁，体重指数（BMI）27.2±5.8，损伤平面（LOI）C4 - L1；女性：42.0±13.5岁，BMI 27.8±6.6，LOI C4 - T11）。不适用。利用磁共振成像评估内脏（VAT）、皮下（SAT）和躯干总（TTAT）脂肪组织体积，并计算VAT:SAT比值。根据标准技术评估促炎脂肪因子（肿瘤坏死因子-α、白细胞介素-6、纤溶酶原激活物抑制剂-1、凝血酶激活的纤溶抑制物和高敏C反应蛋白）以及心血管、碳水化合物和脂质指标。男性SCI参与者的VAT和VAT:SAT比值显著更高（P≤0.002），而女性SCI参与者的SAT体积显著更大（P = 0.001）。两组间TTAT无差异（P = 0.341）。与女性相比，男性SCI参与者的高密度脂蛋白胆固醇（HDLC）水平较低，总胆固醇与HDLC比值升高（P≤0.003）。两组在心脏代谢指标或促炎脂肪因子方面未发现其他显著差异；然而，男性总体指标较差。促炎脂肪因子与按性别分类的脂肪组织储存显著相关（P < 0.05）。结果表明，性别影响脂肪组织分布，并可能影响SCI后的促炎和心脏代谢指标。本研究结果强调需要进一步研究饮食调整和运动以降低健康风险。
