同源异型框基因数据库（HomeoDB）：一个关于同源异型框基因多样性的数据库。

HomeoDB: a database of homeobox gene diversity.

作者信息

Zhong Ying-Fu, Butts Thomas, Holland Peter W H

机构信息

Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China.

出版信息

Evol Dev. 2008 Sep-Oct;10(5):516-8. doi: 10.1111/j.1525-142X.2008.00266.x.

DOI:10.1111/j.1525-142X.2008.00266.x

PMID:18803769

Abstract

The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals. Comparative study of homeobox genes, both within and between species, requires an evolutionary-based classification. HomeoDB was designed and implemented as a manually curated database to collect and present homeobox genes in an evolutionarily structured way, allowing genes, gene families and gene classes to be compared between species more readily than was possible previously. In its first release, HomeoDB includes all homeobox genes from human, amphioxus (Branchiostoma floridae) and fruitfly (Drosophila melanogaster); additional species can be added. HomeoDB is freely accessible at (http://homeodb.cbi.pku.edu.cn).

摘要

同源异型框基因是一个庞大且多样的基因群体，其中许多基因在动物胚胎发育过程中发挥着重要作用。对同源异型框基因在物种内部和物种之间进行比较研究，需要基于进化的分类。HomeoDB被设计并实现为一个人工整理的数据库，以一种进化结构的方式收集和呈现同源异型框基因，使得基因、基因家族和基因类别在物种之间的比较比以往更容易。在其首次发布时，HomeoDB包含了来自人类、文昌鱼（佛罗里达文昌鱼）和果蝇（黑腹果蝇）的所有同源异型框基因；还可以添加其他物种。可通过（http://homeodb.cbi.pku.edu.cn）免费访问HomeoDB。