法国女性及其新生儿对溴化阻燃剂的暴露评估：母体脂肪组织、血清、母乳和脐带血清中三至十溴联苯醚（PBDE）的测定。

Exposure assessment of French women and their newborn to brominated flame retardants: determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum.

作者信息

Antignac Jean-Philippe, Cariou Ronan, Zalko Daniel, Berrebi Alain, Cravedi Jean-Pierre, Maume Daniel, Marchand Philippe, Monteau Fabrice, Riu Anne, Andre François, Le Bizec Bruno

机构信息

Laboratoire d'Etude des Résidus et Contaminants dans les Aliments, USC INRA 2013, Ecole Nationale Vétérinaire de Nantes, Route de Gachet, BP 50707, 44307 Nantes Cedex 3, France.

出版信息

Environ Pollut. 2009 Jan;157(1):164-73. doi: 10.1016/j.envpol.2008.07.008. Epub 2008 Sep 19.

DOI:10.1016/j.envpol.2008.07.008

PMID:18804904

Abstract

In the frame of a French monitoring program, tri- to deca- polybromodiphenylethers (PBDE) have been measured in maternal and cord serum, adipose tissue, and breast milk samples, collected from 93 volunteer women during caesarean deliveries. The seven major tri- to heptaBDE (BDE-28, 47, 99, 100, 153, 154, and 183) were detected in adipose tissue and breast milk with cumulated median values of 2.59 and 2.51 ng g(-1) l w. Nine highly brominated octa- to decaBDE (BDE-196, 197, 201, 202, 203, 206, 207, 208 and 209) was performed in the same samples, with cumulated median values of 2.73 and 3.39 ng g(-1) l w in adipose tissue and breast milk, respectively. At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively.

摘要

在一项法国监测项目中，对从93名剖宫产志愿女性收集的母体和脐带血清、脂肪组织及母乳样本中的三至十溴二苯醚（PBDE）进行了测定。在脂肪组织和母乳中检测到了七种主要的三至七溴二苯醚（BDE - 28、47、99、100、153、154和183），累积中位数分别为2.59和2.51 ng g⁻¹ lw。在相同样本中对九种高溴化八至十溴二苯醚（BDE - 196、197、201、202、203、206、207、208和209）进行了检测，脂肪组织和母乳中的累积中位数分别为2.73和3.39 ng g⁻¹ lw。相反，母体和脐带血清中八至十溴二苯醚的中位数水平明显高于相同基质中三至七溴二苯醚的水平，即分别为8.85和12.34 ng g⁻¹ lw与0.98和0.69 ng g⁻¹ lw。