Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona, Barcelona, Catalonia, Spain.
Environ Int. 2011 Jan;37(1):152-7. doi: 10.1016/j.envint.2010.08.011. Epub 2010 Sep 22.
Polybromodiphenyl ethers (PBDEs) were analyzed in blood serum of pregnant women and in cord blood serum of their newborns from a general population cohort (n = 174; Valencia, Spain). The most abundant PBDE congeners identified were BDE 47, BDE 99, BDE 153, BDE 154 and BDE 209. Their cord blood serum concentrations were about 45% of those in maternal serum but after lipid normalization about the same concentrations were observed in both types of samples. Thus, median of total PBDEs was 9.6 ng/g lipid in cord serum (range between not detected and 140 ng/g lipid) and 9.6 ng/g lipid in maternal serum (range between not detected and 120 ng/g lipid). The distributions of these compounds were dominated by BDE 47 in both cases. In cord blood serum the decreasing order of abundance was BDE 47>BDE 99>BDE 209>BDE 153>BDE 154. The congener composition in maternal serum followed a similar trend: BDE 47>BDE 153>BDE 154>BDE 209>BDE 99. The congener concentrations exhibited a higher degree of correlation in cord blood than in maternal serum. Use of the maternal determinants for categorization of the observed maternal and fetal PBDE concentrations only showed significant associations for the levels in umbilical cord. Neonates from rural areas exhibited statistically significantly lower concentrations than those from urban, semi-urban or metropolitan sites. Maternal serum also showed this difference but the higher dispersion of the concentrations in maternal serum did not afford its recognition with statistical significance. The lower qualitative and quantitative variability in the PBDE concentrations of cord blood serum than maternal serum suggest that the latter is reflecting PBDE contributions from a wider diversity of sources than the former whereas cord blood sera seem to represent the long term standing stock of these compounds accumulated in the maternal tissues.
多溴二苯醚（PBDEs）在来自普通人群队列的孕妇血清和新生儿脐带血清中进行了分析（n=174；西班牙巴伦西亚）。鉴定出的最丰富的 PBDE 同系物为 BDE-47、BDE-99、BDE-153、BDE-154 和 BDE-209。它们的脐带血清浓度约为母体血清的 45%，但经脂质归一化后，两种类型的样本中观察到的浓度大致相同。因此，脐带血清中总 PBDE 的中位数为 9.6ng/g 脂质（范围为未检出到 140ng/g 脂质），母体血清中为 9.6ng/g 脂质（范围为未检出到 120ng/g 脂质）。这些化合物的分布在两种情况下均以 BDE-47 为主。在脐带血清中，丰度递减顺序为 BDE-47>BDE-99>BDE-209>BDE-153>BDE-154。母体血清中的同系物组成也呈现出类似的趋势：BDE-47>BDE-153>BDE-154>BDE-209>BDE-99。脐带血清中的同系物浓度相关性高于母体血清。使用母体决定因素对母体和胎儿 PBDE 浓度进行分类，仅对脐带的浓度显示出显著关联。来自农村地区的新生儿的浓度明显低于来自城市、半城市或大都市地区的新生儿。母体血清也表现出这种差异，但母体血清中浓度的更高分散度并未使其能够以统计学意义识别。脐带血清中 PBDE 浓度的定性和定量变异性均低于母体血清，表明后者反映了 PBDE 来自比前者更广泛的来源的贡献，而脐带血清似乎代表了在母体组织中积累的这些化合物的长期存量。
