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用于诊断检测的蛋白质微阵列。

Protein microarrays for diagnostic assays.

作者信息

Hartmann Michael, Roeraade Johan, Stoll Dieter, Templin Markus F, Joos Thomas O

机构信息

School of Chemical Science and Engineering, Department of Analytical Chemistry, Royal Institute of Technology, 10044, Stockholm, Sweden.

出版信息

Anal Bioanal Chem. 2009 Mar;393(5):1407-16. doi: 10.1007/s00216-008-2379-z. Epub 2008 Sep 20.

Abstract

Protein microarray technology has enormous potential for in vitro diagnostics (IVD). Miniaturized parallelized immunoassays are perfectly suited to generating a maximum of diagnostically relevant information from minute amounts of sample whilst only requiring small amounts of reagent. Protein microarrays have become well-established research tools in basic and applied research and the first products are already on the market. This article reviews the current state of protein microarrays and discusses developments and future demands relating to protein arrays in their role as multiplexed immunoassays in the field of diagnostics.

摘要

蛋白质微阵列技术在体外诊断(IVD)方面具有巨大潜力。小型化并行免疫测定非常适合从微量样品中生成最大量的诊断相关信息,同时仅需少量试剂。蛋白质微阵列已成为基础研究和应用研究中成熟的研究工具,首批产品已投放市场。本文综述了蛋白质微阵列的现状,并讨论了其作为诊断领域多重免疫测定的蛋白质阵列的发展及未来需求。

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