Takahashi T, Kawashima M
Department of Avian Endocrinology, Gifu University, Yanagido, Gifu 501-1193, Japan.
Poult Sci. 2008 Oct;87(10):2107-11. doi: 10.3382/ps.2008-00076.
The present study was performed to elucidate whether mesotocin (MT), one of avian neurohypophysial hormones, relates to the action of arginine vasotocin (AVT) on oviposition of hens. The ratio of AVT-induced oviposition was increased when 1 microg/hen of MT was injected together with AVT. An intravenous injection of 1 microg/hen of MT caused an increase in the binding affinity of the uterine AVT receptor and a decrease in the binding capacity. Blood MT concentrations measured by RIA increased approximately 1 min before oviposition during the period of the bearing-down behavior, but the AVT concentration did not change at this time. The blood AVT concentration dramatically increased within 1 min just after oviposition. The results suggest that MT may have an effect of enhancing the inducing oviposition by AVT through the increase in the sensitivity of the uterus to AVT at oviposition in hens.
本研究旨在阐明鸟类神经垂体激素之一的中催产素（MT）是否与精氨酸血管加压催产素（AVT）对母鸡产卵的作用有关。当将1微克/只的MT与AVT一起注射时，AVT诱导产卵的比例增加。静脉注射1微克/只的MT会导致子宫AVT受体的结合亲和力增加，结合容量降低。在临产前的下压行为期间，通过放射免疫分析测定的血液MT浓度在产卵前约1分钟增加，但此时AVT浓度没有变化。产卵后1分钟内血液AVT浓度急剧增加。结果表明，MT可能通过增加母鸡产卵时子宫对AVT的敏感性，具有增强AVT诱导产卵的作用。
