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[多尔日县儿童结核病感染的当前发病率]

[Current incidence of tubercular infection in children in the Dolj district].

作者信息

Golli V

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1976 Oct-Dec;25(4):209-16.

PMID:188108
Abstract

A lot of 122459 children under the age of 14 were tested intradermally with 2 U PPD. Most of them had been vaccinated at birth and some revaccinated later during the 1966-1967 period, which does not represent interpretation of the prevalance of tuberculosis today, bearing in mind the low postvaccinal allergy of young children and the interval after the last vaccination, only the children with a reaction of more than 10 mm in diameter were taken into consideration as they represented the highest probability of the actual spread of the infection. In the age group up to 6 years 6.82% of the children were infected and 17.12% of the school children of grades II to VIII, i.e. less than the mean values recorded in the whole country. This was attributed to the intensive specific chemotherapy applied within the area. The prevalence gradually increased from 3.93% at the age of l year to 4.90% at 3 years, then sharply to 6.93% at 4 years (when the child's relations are extended) and 10.46% at 5 years. The proportion of infections was of 12--13% in grades II--IV (7-9 years), 16.63% in grade V, 20% in grade VI and 23.21% in grade VIII (13-14 years). The present values are much lower than those recorded in 1966. The present risk of infection is of 1%, with an annual decrease rate of 7%, starting in 1956. By comparison with the published data it is considered that neutralization by chemotherapy of all bacilli carriers will accelerate the rate of decrease of infection.

摘要

对122459名14岁以下儿童进行了2单位结核菌素纯蛋白衍生物(PPD)的皮内试验。他们大多数在出生时接种了疫苗,部分儿童在1966 - 1967年期间再次接种,考虑到幼儿接种后过敏反应较低以及最后一次接种后的时间间隔,这并不能代表当今结核病的流行情况。仅将直径反应超过10毫米的儿童纳入考虑,因为他们代表感染实际传播的最高可能性。在6岁以下年龄组中,6.82%的儿童受到感染,二至八年级的学童中有17.12%受到感染,即低于全国记录的平均值。这归因于该地区实施的强化特异性化疗。患病率从1岁时的3.93%逐渐上升至3岁时的4.90%,然后在4岁时急剧上升至6.93%(此时儿童社交范围扩大),5岁时为10.46%。二至四年级(7 - 9岁)的感染比例为12 - 13%,五年级为16.63%,六年级为20%,八年级(13 - 14岁)为23.21%。目前的值远低于1966年记录的值。从1956年开始,目前的感染风险为1%,年下降率为7%。与已发表的数据相比,认为通过化疗使所有带菌者转阴将加快感染下降速度。

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