Li Yao-Lan, Yeung Chung-Man, Chiu Lawrence C M, Cen Ying-Zhou, Ooi Vincent E C
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Phytother Res. 2009 Jan;23(1):140-2. doi: 10.1002/ptr.2567.
Schefflera heptaphylla (L.) Frodin is a medicinal herb widely used as a main ingredient of the popular health tea formulation against infections in Southern China. Twenty-seven volatile compounds were identified by GC-MS analysis from the essential oil obtained from the leaves of S. heptaphylla, and 17 of them belonged to monoterpenes or sesquiterpenes. The main volatile constituent in S. heptaphylla was found to be a monoterpene, beta-pinene, comprising about 22% of the total volatile components. The essential oil showed significant antiproliferative activity against three cancer cell lines, MCF-7, A375 and HepG2 cells, with IC50 values of 7.3 microg/mL, 7.5 microg/mL and 6.9 microg/mL, respectively. The result of the cytotoxicity assay indicates that (-)-beta-pinene and (+)-beta-pinene (commercially available from Sigma) also possessed antiproliferative activity against the cancer cells MCF-7, A375 and HepG2 with IC50 values ranging from 147.1 to 264.7 microm.
鹅掌柴（Schefflera heptaphylla (L.) Frodin）是一种草药，在中国南方被广泛用作流行的保健茶配方中对抗感染的主要成分。通过气相色谱-质谱联用（GC-MS）分析，从鹅掌柴叶片获得的精油中鉴定出27种挥发性化合物，其中17种属于单萜或倍半萜。发现鹅掌柴中的主要挥发性成分是一种单萜——β-蒎烯，约占总挥发性成分的22%。该精油对三种癌细胞系MCF-7、A375和HepG2细胞显示出显著的抗增殖活性，IC50值分别为7.3微克/毫升、7.5微克/毫升和6.9微克/毫升。细胞毒性试验结果表明，(-)-β-蒎烯和(+)-β-蒎烯（可从Sigma公司购得）对癌细胞MCF-7、A375和HepG2也具有抗增殖活性，IC50值在147.1至264.7微摩尔之间。
