Madan Swati, Singh Gyanendra Nath, Kohli Kanchan, Ali Mohammed, Kumar Yatendra, Singh Raman Mohan, Prakash Om
Central Indian Pharmacopoeia Laboratory, Ministry of Health and Family Welfare, Sector-23, Raj Nagar, Ghaziabad, U.P.-201002, India.
Acta Pol Pharm. 2009 May-Jun;66(3):297-303.
A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone along with the known phytoconstituents: 5,7,2',4'-tetrahydroxyisoflavone (2), 5,7,4'-trihydroxyisoflavone (3) and beta-sitosterol (4). Structure assignments were performed on the basis of spectroscopic data including homo- and heteronuclear 1D and 2D NMR (COSY, HMBC and DEPT) and MS studies. The compounds were tested in vitro for antimicrobial activity and antioxidant activity and compounds (1-3) proved to be moderately active.
从长穗千斤拔（Flemingia strobilifera (L) R. Br.）根部分离得到一种新的异黄酮（1），经鉴定为5,7,4'-三羟基-8,2',5'-三（3-甲基丁-2-烯基）异黄酮，同时还含有已知的植物成分：5,7,2',4'-四羟基异黄酮（2）、5,7,4'-三羟基异黄酮（3）和β-谷甾醇（4）。通过包括同核和异核1D和2D NMR（COSY、HMBC和DEPT）以及MS研究在内的光谱数据进行结构归属。对这些化合物进行了体外抗菌活性和抗氧化活性测试，结果表明化合物（1-3）具有中等活性。
