精神分裂症中端粒酶水平：一项初步研究。
Telomerase levels in schizophrenia: a preliminary study.
作者信息
Porton Barbara, Delisi Lynn E, Bertisch Hilary C, Ji Fei, Gordon Derek, Li Ping, Benedict Melissa M, Greenberg William M, Kao Hung-Teh
机构信息
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
出版信息
Schizophr Res. 2008 Dec;106(2-3):242-7. doi: 10.1016/j.schres.2008.08.028. Epub 2008 Oct 1.
Abstract
We previously demonstrated that telomere length was markedly reduced in peripheral blood lymphocytes from individuals with schizophrenia. Since reduced telomere length can be caused by decreased telomerase activity, we quantitated basal telomerase activity in peripheral blood lymphocytes derived from individuals with schizophrenia (n=53), unaffected relatives (n=31) and unrelated controls (n=59). Telomerase activity varied greatly among individuals, suggesting that this enzymatic activity is affected by various factors. We observed a nominally significant decrease in telomerase activity among individuals with schizophrenia compared to unaffected individuals (unaffected relatives and unrelated controls). Further studies are needed to investigate the role of telomerase in schizophrenia.
摘要
我们之前证明，精神分裂症患者外周血淋巴细胞中的端粒长度显著缩短。由于端粒长度缩短可能是由端粒酶活性降低所致，我们对精神分裂症患者（n = 53）、未患病亲属（n = 31）及无血缘关系的对照者（n = 59）外周血淋巴细胞中的基础端粒酶活性进行了定量分析。个体之间的端粒酶活性差异很大，提示这种酶活性受多种因素影响。我们观察到，与未患病个体（未患病亲属和无血缘关系的对照者）相比，精神分裂症患者的端粒酶活性有名义上的显著降低。需要进一步研究来探究端粒酶在精神分裂症中的作用。
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