Pozza Daniel Humberto, Fregapani Patrícia Wehmeyer, Weber João Batista Blessmann, de Oliveira Marília Gerhardt, de Oliveira Marcos André Matos, Ribeiro Neto Nelson, de Macedo Sobrinho João Batista
Laser Technology, Universidade Federal da Paraíba and Universidade Federal da Bahia, Universidade do Porto, Portugal.
Med Oral Patol Oral Cir Bucal. 2008 Oct 1;13(10):E648-52.
To evaluate the analgesic effect of laser therapy on healthy tissue of mice.
Forty-five animals were divided in three groups of 15: A--infrared laser irradiation (830 nm, Kondortech, São Carlos, SP, Brazil); B--red laser irradiation (660 nm, Kondortech, São Carlos, SP, Brazil); C-- ham irradiation with laser unit off. After laser application, the mice remained immobilized for the injection of 30 microl of 2% formalin in the plantar pad of the irradiated hind paw. The time that the mouse kept the hind paw lifted was measured at 5 min intervals for 30 minutes.
Results showed statistically significant differences comparing the control group with the infrared laser group at 5, 20, 25 and 30 accumulated minutes, and with the red laser group at all time points. The analysis of partial times, at each 5 minutes, showed statistically significant differences between the control and the laser groups up to 20 minutes.
Laser therapy had an analgesic effect and red laser had the best results.
评估激光疗法对小鼠健康组织的镇痛效果。
45只动物被分为三组，每组15只：A组——红外激光照射（830纳米，Kondortech公司，巴西圣保罗州圣卡洛斯市）；B组——红色激光照射（660纳米，Kondortech公司，巴西圣保罗州圣卡洛斯市）；C组——关闭激光装置进行假照射。激光照射后，小鼠保持固定状态，以便在照射后爪的足底垫注射30微升2%的福尔马林。在30分钟内每隔5分钟测量小鼠后爪抬起的时间。
结果显示，在累计5、20、25和30分钟时，对照组与红外激光组相比有统计学显著差异，在所有时间点与红色激光组相比也有统计学显著差异。对每个5分钟的部分时间进行分析显示，对照组与激光组在20分钟内有统计学显著差异。
激光疗法具有镇痛效果，红色激光效果最佳。
