基于碳水化合物稳定的金纳米颗粒信号放大的微重力凝集素生物传感器。
Microgravimetric lectin biosensor based on signal amplification using carbohydrate-stabilized gold nanoparticles.
作者信息
Lyu Young-Ku, Lim Kyung-Rae, Lee Bo Young, Kim Kwan Soo, Lee Won-Yong
机构信息
Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University, Seoul 120-749, Korea.
出版信息
Chem Commun (Camb). 2008 Oct 21(39):4771-3. doi: 10.1039/b807438k. Epub 2008 Aug 4.
DOI:10.1039/b807438k
PMID:18830488
Abstract
A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.
摘要
一种高灵敏度的微重力凝集素生物传感器已被开发出来，它使用碳水化合物稳定的金纳米颗粒作为信号放大器；甘露糖稳定的金纳米颗粒与特异性结合到甘露糖修饰的金石英晶体微天平电极上的目标伴刀豆球蛋白A形成夹心型复合物，从而产生放大的频率响应。
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