Lima-Junior J C, Tran T M, Meyer E V S, Singh B, De-Simone S G, Santos F, Daniel-Ribeiro C T, Moreno A, Barnwell J W, Galinski M R, Oliveira-Ferreira J
Laboratory of Malaria Research, Institute Oswaldo Cruz, Fiocruz, Pavilhao Leonidas Deane, 5th floor, Av. Brasil 4365 - ZIP: 21045-900, Rio de Janeiro, Brazil.
Vaccine. 2008 Dec 2;26(51):6645-54. doi: 10.1016/j.vaccine.2008.09.029.
Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.
在一项横断面研究中，对生活在巴西朗多尼亚州一个原生河畔社区里贝里尼亚和一个移民社区科利纳、自然暴露于疟疾感染的个体，评估了其对间日疟原虫裂殖子表面蛋白9（PvMSP9）的抗体和T细胞反应性。与科利纳相比，里贝里尼亚对PvMSP9 - RIRII和PvMSP9 - Nt结构域的抗体反应更高，且与年龄和疟疾暴露时间相关。在两个社区中，IgG2对PvMSP9 - RII最为普遍，而在里贝里尼亚，IgG1是PvMSP9 - Nt和PvMSP9 - RIRII的主要亚型。在里贝里尼亚，IFN - γ和IL - 4占主导，而在科利纳，IFN - γ占主导。间日疟原虫暴露的差异可能是所研究的两个人群在细胞因子和抗体水平上观察到差异的原因。
