Carmeli Eli, Beiker Reut, Morad Mohammed
Department of Physical Therapy, Sackler Faculty of Medicine, Stanley, Steyer School of Health Professions, Tel Aviv University, Ramat Aviv 69978, Israel.
Res Dev Disabil. 2009 May-Jun;30(3):567-71. doi: 10.1016/j.ridd.2008.08.004. Epub 2008 Oct 1.
Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. The role of NO and IL-6 in the neuropathogenesis of brain seizures is still questionable. In order to evaluate the role of NO and IL-6 in neurological disorders such as seizures, we investigated 19 adults with intellectual disability (ID) who suffer from epilepsy and treated for convulsions. NO metabolites (NOx) and IL-6 levels in serum obtained after night-sleep were significantly high among ID individuals diagnosed with epilepsy versus ID people without epilepsy. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Consequently, we suggest that professionals consider chemical inhibitors that might be helpful against the function of NO and IL-6.
一氧化氮（NO）和白细胞介素-6（IL-6）是高反应性介质，已被证明在多种不同的生物学过程中发挥不同作用。NO和IL-6在癫痫发作的神经发病机制中的作用仍存在疑问。为了评估NO和IL-6在癫痫等神经系统疾病中的作用，我们调查了19名患有智力障碍（ID）且患有癫痫并接受惊厥治疗的成年人。与无癫痫的ID个体相比，被诊断患有癫痫的ID个体夜间睡眠后血清中的NO代谢产物（NOx）和IL-6水平显著升高。这些结果表明，NOx和IL-6可能在惊厥中具有病理生理作用。因此，我们建议专业人员考虑使用可能有助于对抗NO和IL-6功能的化学抑制剂。
