ITGA2 C807T 多态性与胃癌风险的关联。
Association between ITGA2 C807T polymorphism and gastric cancer risk.
机构信息
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2011 Jun 21;17(23):2860-6. doi: 10.3748/wjg.v17.i23.2860.
Abstract
AIM
To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.
METHODS
A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.
RESULTS
The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.
CONCLUSION
The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.
摘要
目的
评估 ITGA2 基因多态性对胃癌风险的影响。
方法
采用基于医院的病例对照研究，纳入 307 例胃癌患者和 307 例年龄和性别匹配的对照。通过聚合酶链反应-限制性片段长度多态性分析鉴定基因型。
结果
病例组和对照组的野生和变异基因型频率存在显著差异（P = 0.019）。与野生基因型 CC 的个体相比，携带变异基因型（CT + TT）的个体患胃癌的风险显著升高（调整后的优势比 = 1.57，95%CI = 1.13-2.17，P = 0.007）。在分层分析中，在年龄 > 58 岁、不吸烟者和农村人群中，这种升高的胃癌风险更为明显。进一步的分析表明，在胃癌患者的亚分析中，变异基因型与肿瘤分化不良和邻近器官侵犯有关。
结论
ITGA2 基因 C807T 多态性可能与胃癌风险增加、胃癌分化和侵袭有关。
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