Smith Kristen N, Queenan Katie M, Thomas William, Fulcher R Gary, Slavin Joanne L
Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.
J Am Coll Nutr. 2008 Jun;27(3):434-40. doi: 10.1080/07315724.2008.10719722.
Barley fiber rich in beta-glucans lowers serum lipids, but is difficult to incorporate into products acceptable to consumers. We investigated the physiological effects of two concentrated barley beta-glucans on cardiovascular disease (CVD) endpoints and body weight in human subjects.
Hypercholesterolemic men and women (n = 90) were randomly assigned to one of two treatments: low molecular weight (low-MW) or high molecular weight (high-MW) concentrated barley beta-glucan consumed as a daily supplement containing 6 grams beta-glucan/day. Fasting blood samples were collected at baseline and week 6 and analyzed for total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, homocysteine and C-reactive protein (CRP). Dietary intakes, body weights, blood pressure, hunger ratings, and gastrointestinal symptoms were measured at baseline and 6 weeks.
The only difference between treatments in lipid outcomes at week 6 was a reduction of the cholesterol/HDL ratio in the low-MW group and a small increase in the high-MW group. No changes were found in blood pressure, glucose, insulin, and gastrointestinal symptoms. Body weight decreased from baseline to 6 weeks in the high-MW group while body weight increased in the low-MW group. Levels of hunger decreased slightly in the low-MW group and decreased significantly in the high-MW group (P = 0.02)
Overall, supplementation with isolated barley beta-glucans of different molecular weights had small effects on cardiovascular disease markers. Molecular weight of the barley fiber did alter effects on body weight with the high-MW fiber significantly decreasing body weight.
富含β-葡聚糖的大麦纤维可降低血脂，但难以融入消费者可接受的产品中。我们研究了两种浓缩大麦β-葡聚糖对人体心血管疾病（CVD）终点指标和体重的生理影响。
高胆固醇血症的男性和女性（n = 90）被随机分配到两种治疗方法之一：低分子量（低-MW）或高分子量（高-MW）浓缩大麦β-葡聚糖，作为每日补充剂食用，每天含有6克β-葡聚糖。在基线和第6周采集空腹血样，分析总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、葡萄糖、胰岛素、同型半胱氨酸和C反应蛋白（CRP）。在基线和6周时测量饮食摄入量、体重、血压、饥饿评分和胃肠道症状。
第6周时，两种治疗方法在血脂结果上的唯一差异是低分子量组的胆固醇/高密度脂蛋白比值降低，而高分子量组略有增加。血压、葡萄糖、胰岛素和胃肠道症状均未发现变化。高分子量组的体重从基线降至6周，而低分子量组的体重增加。低分子量组的饥饿水平略有下降，高分子量组则显著下降（P = 0.02）
总体而言，补充不同分子量的分离大麦β-葡聚糖对心血管疾病标志物的影响较小。大麦纤维的分子量确实会改变对体重的影响，高分子量纤维可显著降低体重。
