色酮从色酮-四氧化三铁纳米颗粒中的pH控制释放。
pH controlled release of chromone from chromone-Fe3O4 nanoparticles.
作者信息
Wang Baodui, Xu Chenjie, Xie Jin, Yang Zhengyin, Sun Shouheng
机构信息
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
出版信息
J Am Chem Soc. 2008 Nov 5;130(44):14436-7. doi: 10.1021/ja806519m. Epub 2008 Oct 8.
Abstract
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.
摘要
我们报道了一种将色酮与Fe3O4纳米颗粒偶联的新策略。色酮-Fe3O4纳米颗粒共轭物显示色酮在细胞培养基中的溶解度从小于2.5微克/毫升急剧增加到633微克/毫升，导致HeLa细胞对色酮的摄取增强。色酮可以在低pH值下释放，因此，色酮-Fe3O4共轭物在抑制HeLa细胞增殖方面效率更高。这种色酮-Fe3O4纳米颗粒有望成为一种强大的多功能递送系统，用于基于色酮的诊断和治疗应用。
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