利用热降解偶氮功能化聚乙二醇包覆的核壳介孔二氧化硅纳米颗粒进行磁场激活药物递送。
Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core-shell mesoporous silica nanoparticles.
作者信息
Saint-Cricq P, Deshayes S, Zink J I, Kasko A M
机构信息
Department of Chemistry and Biochemistry, and California NanoSystems Institute, University of California Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Bioengineering Department, and California NanoSystems Institute University of California Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095-1600, United States.
出版信息
Nanoscale. 2015 Aug 21;7(31):13168-13172. doi: 10.1039/c5nr03777h. Epub 2015 Jul 16.
Abstract
Core-shell Fe3O4@SiO2 mesoporous silica nanoparticles coated with a new thermodegradable polymer allowed the release of a model drug through heating caused by a high frequency oscillating magnetic field. The thermodegradable polymer was made of poly(ethylene glycol) (PEG) functionalised with azo bonds that break with an elevation of temperature.
摘要
包覆有新型热降解聚合物的核壳结构Fe3O4@SiO2介孔二氧化硅纳米粒子，可通过高频振荡磁场产生的加热作用来实现模型药物的释放。该热降解聚合物由用偶氮键官能化的聚乙二醇（PEG）制成，偶氮键会随温度升高而断裂。
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