Andersen Klaus Ejner, Christensen Lars Porskjaer, Vølund Aage, Johansen Jeanne Duus, Paulsen Evy
Department of Dermatology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Contact Dermatitis. 2009 Mar;60(3):155-7. doi: 10.1111/j.1600-0536.2008.01498.x.
Both epoxy resin (diglycidyl ether of bisphenol A) and fragrance mix I are included in the European baseline series of contact allergens. A significant association between positive reactions to epoxy resin and fragrance mix has been reported by others.
To investigate and possibly reproduce this association with the use of TRUE((R)) test data and supplementary tests with fragrance mix ingredients from the Department of Dermatology, Odense University Hospital.
Six thousand one hundred and fifteen consecutive eczema patients tested from 1995 to 2007 were included, and test results from all patients tested with fragrance mix ingredients were analysed.
One hundred and forty-five (2.4%) were positive to epoxy resin and 282 (4.6%) were positive to fragrance mix I. Nineteen were positive to both giving an odds ratio of 3.3, which is significant (95% CI 2.0-5.4). Analysis of association to individual fragrance mix ingredients showed a significant association to alpha-amyl cinnamal and isoeugenol.
The significant association between positive reactions to epoxy resin and fragrance mix I was reproduced. However, the clinical implications are not clarified, and even though the association may be coincidental, the fact that it can be reproduced with a different patch test system and in a different population speaks against a random result. Further studies may help to interpret the association.
环氧树脂（双酚A二缩水甘油醚）和香料混合物I均包含在欧洲接触性变应原基线系列中。其他人已报告环氧树脂和香料混合物阳性反应之间存在显著关联。
利用奥登塞大学医院皮肤科的TRUE((R))试验数据及香料混合物成分补充试验来研究并可能重现这种关联。
纳入1995年至2007年连续检测的6115例湿疹患者，并分析所有用香料混合物成分检测患者的试验结果。
145例（2.4%）对环氧树脂呈阳性，282例（4.6%）对香料混合物I呈阳性。19例两者均呈阳性，比值比为3.3，具有显著性（95%可信区间2.0 - 5.4）。与单个香料混合物成分的关联分析显示与α - 戊基肉桂醛和异丁香酚存在显著关联。
重现了环氧树脂和香料混合物I阳性反应之间的显著关联。然而，临床意义尚未阐明，尽管这种关联可能是巧合，但能用不同的斑贴试验系统并在不同人群中重现这一事实表明并非随机结果。进一步研究可能有助于解释这种关联。
