Zemel Michael B, Sun Xiaocun
The Department of Nutrition, The University of Tennessee, Knoxville, Tennessee 37996-1920, USA.
Nutr Rev. 2008 Oct;66(10 Suppl 2):S139-46. doi: 10.1111/j.1753-4887.2008.00099.x.
Calcitriol, a calcitrophic hormone that can be suppressed by high dietary calcium, favors fatty acid synthesis and inhibits lipolysis via non-genomic modulation of Ca(2+) influx. Calcitriol also suppresses UCP2 expression via the nVDR and thereby increases energy efficiency. Calcitriol exerts a dose-dependent impact on adipocyte apoptosis and regulates adipose tissue fat depot location and expansion by promoting glucocorticoid production and release. Recent data also demonstrate a pivotal role of calcitriol in the modulation of cytokines, with potential roles in energy metabolism in adipocytes, macrophages, and skeletal muscle.
骨化三醇是一种可被高钙饮食抑制的促钙激素，它有利于脂肪酸合成，并通过对钙离子内流的非基因组调节来抑制脂肪分解。骨化三醇还通过核维生素D受体抑制解偶联蛋白2（UCP2）的表达，从而提高能量效率。骨化三醇对脂肪细胞凋亡具有剂量依赖性影响，并通过促进糖皮质激素的产生和释放来调节脂肪组织脂肪储存的位置和扩张。最近的数据还表明骨化三醇在细胞因子调节中起关键作用，在脂肪细胞、巨噬细胞和骨骼肌的能量代谢中具有潜在作用。
