在日托中心有幼儿的女性中怀孕的频率以及接触巨细胞病毒感染的情况。
The frequency of pregnancy and exposure to cytomegalovirus infections among women with a young child in day care.
作者信息
Marshall Beth C, Adler Stuart P
机构信息
Department of Pediatrics, Medical of College of Virginia Campus, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
出版信息
Am J Obstet Gynecol. 2009 Feb;200(2):163.e1-5. doi: 10.1016/j.ajog.2008.08.037. Epub 2008 Oct 9.
OBJECTIVE
The purpose of this study was to determine the frequency of pregnancy and exposure to cytomegalovirus (CMV) among mothers contemplating a possible additional pregnancy and with a child less than 2 years of age in group day care.
STUDY DESIGN
We performed a prospective observational study that included a demographic questionnaire and serologic and virologic monitoring of mothers and their children in day care.
RESULTS
Of 60 women, 62% were seronegative and 20% had a child shedding CMV. Of the 60 women, 23 women or 38% (95% CI, 0.27-0.51) became pregnant on average 10 months after enrollment. During pregnancy, 8 or 35% (95% CI, 0.19-0.55) of these pregnant women had a child in day care who shed CMV.
CONCLUSION
These results illustrate the potential magnitude of the public problem associated with exposure to a silent viral infection during pregnancy. Our data, when extrapolated to the US population, estimate that every 2 years between 31,000 and 168,000 susceptible pregnant women will be exposed to CMV by an infected child.
目的
本研究旨在确定在日托机构中考虑再次怀孕且孩子年龄小于2岁的母亲中，怀孕的频率以及巨细胞病毒（CMV）暴露情况。
研究设计
我们进行了一项前瞻性观察性研究，包括对母亲及其在日托机构中的孩子进行人口统计学问卷调查、血清学和病毒学监测。
结果
60名女性中，62%血清学阴性，20%的孩子排出CMV。60名女性中，23名女性（38%，95%CI，0.27 - 0.51）在入组后平均10个月怀孕。怀孕期间，这些孕妇中有8名（35%，95%CI，0.19 - 0.55）在日托机构中的孩子排出CMV。
结论
这些结果说明了怀孕期间暴露于无症状病毒感染所带来的公共问题的潜在严重程度。我们的数据外推至美国人群后估计，每两年有31,000至168,000名易感孕妇会因受感染的孩子而暴露于CMV。
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