Plebani M, Di Mario F, Vianello F, Giordano A, Masiero M, Lazzaretto M, Farini R, Ceriotti G, Naccarato R
Clin Biochem. 1983 Feb;16(1):20-2. doi: 10.1016/s0009-9120(83)94279-0.
Pepsinogens, proteolytic enzymes produced by peptic cells of the stomach and discharged into the gastric lumen as well as into the blood have been divided into two groups: PG-I, originating from chief cells, and PG-II, mainly from antrum peptic cells. Both total serum pepsinogen (s-Pg) and PG-I have been separately reported as being significantly increased in gastric (GU) and duodenal ulcer (DU) patients and related to maximal acid output. In order to ascertain the relationship between s-Pg measured by means of the colorimetric Uete method, and PG-I determined by RIA method, these were assayed in 72 control subjects, 35 GU and 95 DU patients. s-Pg was found to be significantly increased both in GU and DU patients in comparison with control subjects. Likewise PG-I was significantly enhanced in GU and DU patients as compared with controls. A significant direct correlation between s-Pg and PG-I was found in all the subjects studied (r = 0.732).
胃蛋白酶原是由胃的主细胞产生并排入胃腔和血液的蛋白水解酶，已被分为两组：PG-I，起源于主细胞；PG-II，主要来自胃窦主细胞。血清总胃蛋白酶原（s-Pg）和PG-I均分别被报道在胃溃疡（GU）和十二指肠溃疡（DU）患者中显著升高，并与最大胃酸分泌量相关。为了确定用比色法Uete法测定的s-Pg与用放射免疫分析法（RIA）测定的PG-I之间的关系，对72名对照受试者、35名GU患者和95名DU患者进行了检测。发现GU和DU患者的s-Pg均较对照受试者显著升高。同样，与对照组相比，GU和DU患者的PG-I也显著升高。在所有研究对象中，s-Pg与PG-I之间存在显著的正相关（r = 0.732）。
