Oettlé G J
Department of Surgery, Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.
Gut. 1991 Aug;32(8):941-4. doi: 10.1136/gut.32.8.941.
Ten healthy volunteers (six men and four women, aged 22-41 years) were studied in a crossover trial. The study was divided into three one week periods. During each period the subjects either ran on a treadmill, cycled on a bicycle ergometer, or rested in a chair for 1 hour every day. The exercise was performed at two thirds predicted maximum heart rate (equivalent to 50% VO2 max). The sequences were rotated; no studies were performed in the perimenstrual period. Transit was measured by the method of measuring the excretion of a single dose of radio-opaque markers; all stools were collected, weighed, and x rayed after the ingestion of radio-opaque markers. Dietary fibre and fluid intake were measured on the fourth day of each test period by 24 hour record. Lifestyle was otherwise unchanged. Transit time was dramatically accelerated by moderate exercise (both jogging and cycling); however, stool weight, defecation frequency, dietary fibre intake, and fluid intake did not change significantly. Whole gut transit changed from 51.2 hours (95% confidence intervals 41.9 to 60.5) at rest to 36.6 hours (31.6 to 39.2) when riding and 34.0 hours (28.8 to 39.2) when jogging. Riding and running both differed significantly from resting (p less than 0.01); the difference between riding and running was not significant.
十名健康志愿者（六名男性和四名女性，年龄在22 - 41岁之间）参与了一项交叉试验。该研究分为三个为期一周的阶段。在每个阶段，受试者每天要么在跑步机上跑步，要么在自行车测力计上骑行，要么在椅子上休息1小时。运动强度为预计最大心率的三分之二（相当于最大摄氧量的50%）。试验顺序是轮换的；在月经周期内不进行研究。通过测量单剂量不透射线标记物的排泄来测定转运时间；在摄入不透射线标记物后，收集所有粪便，称重并进行X光检查。在每个测试阶段的第四天，通过24小时记录来测量膳食纤维和液体摄入量。其他生活方式保持不变。适度运动（慢跑和骑行）显著加快了转运时间；然而，粪便重量、排便频率、膳食纤维摄入量和液体摄入量没有明显变化。全肠道转运时间从休息时的51.2小时（95%置信区间为41.9至60.5）变为骑行时的36.6小时（31.6至39.2）和慢跑时的34.0小时（28.8至39.2）。骑行和跑步时的转运时间与休息时均有显著差异（p < 0.01）；骑行和跑步之间的差异不显著。
