Fung C H, Lo J W, Yonan T N, Milloy F J, Hakami M M, Changus G W
Cancer. 1977 Jan;39(1):153-63. doi: 10.1002/1097-0142(197701)39:1<153::aid-cncr2820390126>3.0.co;2-#.
A pulmonary blastoma is reported in a 19-year-old black female. The light and electron microscopic characterics are described; they are found to be similar to those of the fetal lung prior to the fourth gestational month. Although the ultrastructural features do not favor any particular theory of histogenesis of this unique tumor, evidence for the commonly held theory that the tumor arises from pluipotential pulmonary blastema seems tenuous. A brief review of the literature disclosed 38 other similar cases. There was a male predominance with an average age of detection at 39 years. Sputum cytology was rarely positive. Among tumors larger than 5 cm in diameter, survival was usually less than 2 years. Metastases were present in approximately half of the cases.
本文报道了一名19岁黑人女性的肺母细胞瘤。描述了其光镜和电镜特征；发现这些特征与妊娠第四个月前的胎儿肺相似。尽管超微结构特征不支持关于这种独特肿瘤组织发生的任何特定理论，但肿瘤起源于多能肺胚基这一普遍观点的证据似乎并不充分。对文献的简要回顾发现了另外38例类似病例。男性居多，平均确诊年龄为39岁。痰细胞学检查很少呈阳性。在直径大于5厘米的肿瘤中，生存率通常不到2年。约一半病例存在转移。
