Morino Mario, Parini Umberto, Allaix Marco Ettore, Monasterolo Gabriella, Brachet Contul Riccardo, Garrone Corrado
Chirurgia Generale II, Center for Minimally Invasive Surgery, Department of Surgery, University of Turin, C.so A. M. Dogliotti, 14, 10126, Torino, Italy.
Surg Endosc. 2009 Jun;23(6):1233-40. doi: 10.1007/s00464-008-0136-1. Epub 2008 Oct 15.
Urinary and sexual dysfunction are potential complications of rectal surgery for cancer. This study retrospectively evaluated the frequency of such complications after laparoscopic total mesorectal excision (LTME) with autonomic nerve preservation.
For this study, 50 men younger than 75 years who underwent radical LTME for mid and low rectal cancer were followed up for at least 12 months, interviewed, and administered a standardized questionnaire about postoperative functional outcomes and quality of life.
Sexual desire was maintained by 55.6%, ability to engage in intercourse by 57.8%, and ability to achieve orgasm and ejaculation by 37.8% of the patients. Distance of the tumor from the anal verge and adjuvant or neoadjuvant treatments were the significant predictors of poor postoperative sexual function. Seven patients (14%) presented transitory postoperative urinary dysfunction, all of whom were medically treated. Tumor stage and distance from the anal verge were independently associated with the postoperative global International Prostatic Symptom Score (IPSS). No differences were observed in urinary quality of life.
In this series, LTME did not reproduce or improve on sexual and urinary dysfunction outcomes obtained in the best open TME series. Further trials are needed to evaluate functional outcome in rectal cancer patients.
泌尿和性功能障碍是直肠癌直肠手术的潜在并发症。本研究回顾性评估了保留自主神经的腹腔镜全直肠系膜切除术(LTME)后此类并发症的发生频率。
本研究对50例年龄小于75岁、因中低位直肠癌接受根治性LTME的男性患者进行了至少12个月的随访,进行访谈并给予一份关于术后功能结局和生活质量的标准化问卷。
55.6%的患者性欲得以维持,57.8%的患者能够进行性交,37.8%的患者能够达到性高潮和射精。肿瘤距肛缘的距离以及辅助或新辅助治疗是术后性功能不良的重要预测因素。7例患者(14%)出现短暂性术后排尿功能障碍,均接受了药物治疗。肿瘤分期和距肛缘的距离与术后总体国际前列腺症状评分(IPSS)独立相关。在尿生活质量方面未观察到差异。
在本系列研究中,LTME并未再现或改善最佳开放性全直肠系膜切除术系列所获得的性功能和排尿功能障碍结局。需要进一步的试验来评估直肠癌患者的功能结局。