用于直接检测宫颈标本中衣原体的快速CLEARVIEW衣原体检测法的评估。
Evaluation of the rapid CLEARVIEW Chlamydia test for direct detection of chlamydiae from cervical specimens.
作者信息
Stratton N J, Hirsch L, Harris F, de la Maza L M, Peterson E M
机构信息
Department of Pathology, University of California, Irvine Medical Center, Orange 92668.
出版信息
J Clin Microbiol. 1991 Jul;29(7):1551-3. doi: 10.1128/jcm.29.7.1551-1553.1991.
The CLEARVIEW Chlamydia test (Unipath, Mountain View, Calif.), a 30-min immunoassay, was compared to a standard tissue culture technique for the direct detection of chlamydiae from 677 cervical specimens obtained from 667 patients. For data analysis, 15 specimens were eliminated because of toxicity in the culture and 14 were eliminated because of failure of the extracted specimen to migrate in the CLEARVIEW test, one of the latter group being culture positive. Of the remaining 648 specimens, 40 were culture positive, of which 38 were detected by the CLEARVIEW test, and 12 specimens were positive only by the CLEARVIEW test. Therefore, the CLEARVIEW in comparison with culture was easier to perform, more rapid, and in this low prevalence (6.2%) population had a 95.0% sensitivity, 98.0% specificity, and 76.0% positive and 99.7% negative predictive values.
将Clearview衣原体检测法（Unipath公司，加利福尼亚州山景城），一种30分钟的免疫测定法，与标准组织培养技术进行比较，以直接从667例患者获取的677份宫颈标本中检测衣原体。为进行数据分析，15份标本因培养时有毒性而被排除，14份标本因提取的标本在Clearview检测中未能迁移而被排除，后一组中有一份培养呈阳性。在其余648份标本中，40份培养呈阳性，其中38份通过Clearview检测法检测出，12份标本仅通过Clearview检测法呈阳性。因此，与培养法相比，Clearview检测法操作更简便、速度更快，在这个低患病率（6.2%）人群中，其灵敏度为95.0%，特异性为98.0%，阳性预测值为76.0%，阴性预测值为99.7%。
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