血管紧张素II对体外灌注兔卵巢的直接作用。
Direct effect of angiotensin II on in-vitro perfused rabbit ovary.
作者信息
Kuo T C, Endo K, Dharmarajan A M, Miyazaki T, Atlas S J, Wallach E E
机构信息
Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Baltimore, MD 21205.
出版信息
J Reprod Fertil. 1991 Jul;92(2):469-74. doi: 10.1530/jrf.0.0920469.
The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.
在离体、体外灌注的兔卵巢中研究了血管紧张素II（AII）及其受体阻滞剂沙拉新（SAR）对排卵和卵母细胞成熟的影响。在不存在人绒毛膜促性腺激素（hCG）的情况下，AII可诱导排卵和卵母细胞成熟。SAR可抑制由AII或hCG诱导的排卵，但不抑制卵母细胞成熟。AII似乎在卵泡破裂中起关键作用，但在卵母细胞减数分裂恢复中不起作用。
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