Johnson C D, Devaux M A, Treffot M J, Sarles H
INSERM U315, Marseille, France.
Pancreas. 1991 Mar;6(2):190-6. doi: 10.1097/00006676-199103000-00010.
We studied post-meal pancreatic secretion and gastrin release in conscious dogs with duodenal Thomas cannulas. Normal dogs were tested in physiological conditions and with an i.v. infusion of atropine 20 micrograms/kg/h or secretin 0.5 CU/kg/h. The responses were also studied after antral and truncal vagotomy. In the early phase (0-20 min) of the response, before gastric emptying started, antral vagotomy reduced fluid and protein outputs, and truncal vagotomy reduced them still more. Atropine reduced only the protein response. Gastrin release reached a peak after 20-25 min. After antral and truncal vagotomy, gastrin release was reduced within 10 min after the meal. Late-phase (greater than 20 min) pancreatic secretion depended on the presence of chyme in the duodenum. The effects of atropine and antral vagotomy in the cephalogastric phase could be explained by antropancreatic reflexes stimulating fluid secretion (atropine-resistant pathway) and protein output (atropine-sensitive pathway).
我们使用十二指肠托马斯插管对清醒犬的餐后胰腺分泌和胃泌素释放进行了研究。正常犬在生理条件下以及静脉输注20微克/千克/小时阿托品或0.5 CU/千克/小时促胰液素的情况下接受测试。在进行胃窦和迷走神经干切断术后也对反应进行了研究。在反应的早期阶段（0 - 20分钟），在胃排空开始之前，胃窦迷走神经切断术减少了液体和蛋白质的分泌量，而迷走神经干切断术使分泌量减少得更多。阿托品仅减少了蛋白质反应。胃泌素释放在20 - 25分钟后达到峰值。在进行胃窦和迷走神经干切断术后，餐后10分钟内胃泌素释放减少。后期（大于20分钟）胰腺分泌取决于十二指肠中食糜的存在。阿托品和胃窦迷走神经切断术在头胃期的作用可以通过刺激液体分泌（阿托品抵抗途径）和蛋白质分泌量（阿托品敏感途径）的胃胰反射来解释。
