Rosenberg I R, Zambrano V J, Janowitz H D, Rudick J
Ann Surg. 1976 Mar;183(3):247-51. doi: 10.1097/00000658-197603000-00005.
The role of the antrum on vagally mediated pancreatic secretion was studied in 8 conscious dogs prepared with chronic pancreatic and gastric fistulae. After completion of control studies 6 were subjected to antrectomy and 2 to antroneurolysis (to interrupt submucosal nerve connections); secretory studies were repeated. With the animals secreting in response to secretin(0.03 u per kg-min) or secretin with cholecystokinin (0.05 u per kg-min), the following were administered: 1) insulin 0.2 u/kg; 2) atropine 0.2 and 0.4 mg/kg; 3) insulin after atropine. Insulin hypoglycemia elicited a marked enzyme response. Both antrectomy and antroneurolysis markedly reduced (80%) the enzyme response to insulin hypoglycemia. Atropine 0.2 mg/kg abolished the insulin response and at 0.4 mg/kg inhibited (50%) the enzyme response to cholecystokinin; these effects were unaltered by antrectomy or antroneurolysis. These experiments suggest that the pancreatic enzyme response to insulin hypoglycemia is predominantly mediated through the vagal release of antral gastrin. Furthermore, antrectomy and antroneurolysis do not affect the enzyme response to cholecystokinin nor do they alter the inhibitory effects of atropine. The inhibitio- by atropine suggests that a cholinergic background exerts a permissive effect on CCK-mediated enzyme secretion.
在8只制备了慢性胰瘘和胃瘘的清醒犬中，研究了胃窦在迷走神经介导的胰腺分泌中的作用。在完成对照研究后，6只犬接受了胃窦切除术，2只犬接受了胃窦神经松解术（以中断黏膜下神经连接）；重复进行分泌研究。当动物对促胰液素（0.03单位/千克·分钟）或促胰液素与胆囊收缩素（0.05单位/千克·分钟）产生分泌反应时，给予以下物质：1）胰岛素0.2单位/千克；2）阿托品0.2和0.4毫克/千克；3）阿托品后给予胰岛素。胰岛素低血糖引起明显的酶反应。胃窦切除术和胃窦神经松解术均显著降低（80%）了对胰岛素低血糖的酶反应。0.2毫克/千克的阿托品消除了胰岛素反应，0.4毫克/千克时抑制（50%）了对胆囊收缩素的酶反应；这些作用不受胃窦切除术或胃窦神经松解术的影响。这些实验表明，胰腺对胰岛素低血糖的酶反应主要通过胃窦胃泌素的迷走神经释放介导。此外，胃窦切除术和胃窦神经松解术不影响对胆囊收缩素的酶反应，也不改变阿托品的抑制作用。阿托品的抑制作用表明胆碱能背景对CCK介导的酶分泌具有允许作用。
