Debas H T, Yamagishi T
Am J Physiol. 1978 May;234(5):E468-71. doi: 10.1152/ajpendo.1978.234.5.E468.
In seven dogs provided with innervated pouch of the pyloric antrum, gastric fistula, and chronic pancreatic fistula, the effect of graded antral distenion on pancreatic exocrine secretion was studied. The effect of antral distension was tested both when gastrin release was promoted (alkaline distention) and when gastrin release was blocked (acid distension). These studies were performed both before and after transthoracic truncal vagotomy. Graded alkaline antral distension caused graded rise in protein-rich pancreatic secretion and graded increase in the concentration of serum immunoreactive gastrin. A similar pancreatic response was also seen with graded acid distention although this time no rise in serum gastrin concentration occurred. Pancreatic response to antral distension with either alkali or acid is completely inhibited by pretreatment of the animals with systemic atropine. Truncal vagotomy reduced pancreatic response to alkaline antral distension by 90% but completely abolished pancreatic response to distension of the antrum with acid. These studies provide evidence for a pyloropancreatic reflex mechanism for pancreatic secretion that is cholinergic and requires intact long vagal pathways.
在7只具备幽门窦神经支配囊袋、胃瘘和慢性胰瘘的犬中，研究了不同程度的胃窦扩张对胰腺外分泌的影响。在促胃液素释放增加时（碱性扩张）和促胃液素释放受阻时（酸性扩张）均测试胃窦扩张的影响。这些研究在经胸迷走神经干切断术前和术后均进行。不同程度的碱性胃窦扩张导致富含蛋白质的胰腺分泌呈分级增加，血清免疫反应性促胃液素浓度也分级升高。在酸性扩张时也观察到类似的胰腺反应，尽管此时血清促胃液素浓度未升高。用全身性阿托品预处理动物后，胰腺对碱性或酸性胃窦扩张的反应均被完全抑制。迷走神经干切断术使胰腺对碱性胃窦扩张的反应降低90%，但完全消除了胰腺对酸性胃窦扩张的反应。这些研究为胰腺分泌的幽门-胰腺反射机制提供了证据，该机制是胆碱能的，且需要完整的迷走神经长通路。
