Furukawa N, Okada H
Department of Physiology, Kawasaki Medical School, Japan.
Jpn J Physiol. 1987;37(4):671-85. doi: 10.2170/jjphysiol.37.671.
In chloralose anesthetized dogs and decerebrated dogs whose pyloric sphincter was submucosally ligated, the pancreatic exocrine secretory response to antral distension was studied. Distensions of the antral pouch with Tyrode's solution and 0.1 N HCl caused graded rises in pancreatic flow and protein and bicarbonate outputs. The serum gastrin concentration gradually rose after the distention with Tyrode's solution, while no rise in serum gastrin was elicited by acid distension. After cervical vagotomy, a reduced pancreatic response persisted but no rise in the serum gastrin was seen. After splanchnicectomy following vagotomy, the pancreatic response became greater than before splanchnicectomy. This pancreatic response was observed even after caeliac and superior mesenteric ganglionectomies, but was completely abolished by an external tight ligature around the pyloric sphincter, or by administration of hexamethonium or atropine sulfate. The results suggest the existence of an antropancreatic short reflex in addition to a long route vago-vagal reflex.
在水合氯醛麻醉的犬以及幽门括约肌经黏膜下结扎的去大脑犬中，研究了胰腺外分泌对胃窦扩张的分泌反应。用台氏液和0.1N盐酸扩张胃窦袋可使胰腺分泌量、蛋白质和碳酸氢盐输出量呈分级增加。用台氏液扩张后血清胃泌素浓度逐渐升高，而酸扩张未引起血清胃泌素升高。颈迷走神经切断术后，胰腺反应减弱但血清胃泌素未见升高。迷走神经切断术后行内脏神经切除术，胰腺反应比内脏神经切除术前增强。即使在腹腔神经节和肠系膜上神经节切除术后仍观察到这种胰腺反应，但幽门括约肌周围的外部紧密结扎、或给予六甲铵或硫酸阿托品可完全消除该反应。结果提示除了长径迷走-迷走反射外，还存在胃-胰短反射。
