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[大鼠均匀内照射(¹³⁷Cs)与局部X射线(睾丸)照射遗传效应的比较评估]

[A comparative evaluation of the genetic effects of uniform internal (137Cs) and local x-ray (testes) irradiation of rats].

作者信息

Vetukh V A, Malakhovskiĭ V N

出版信息

Radiobiologiia. 1991 May-Jun;31(3):302-10.

PMID:1886994
Abstract

In experiments with rats it was shown that with equal absorbed doses after single injection of 137Cs and local X-irradiation of testes the mutation yield in gametes was different when tested by the frequency of dominant lethals and half-lethals, reciprocal translocations, univalents, and chromosome fragments. A higher efficiency of whole-body irradiation as compared to local exposure of testes, with respect to genetic damages induction, and the statistically significant increase in the number of the damages during a long period of time after cessation of the absorbed dose formation indicated that indirect effects of whole-body irradiation contributed to the injury to hereditary structures and permitted to estimate approximately their contribution (up to 50%).

摘要

在对大鼠的实验中发现,单次注射137Cs并对睾丸进行局部X射线照射,在吸收剂量相等的情况下,通过显性致死和半致死频率、相互易位、单价体和染色体片段来检测时,配子中的突变产量是不同的。与睾丸局部照射相比,全身照射在诱导遗传损伤方面效率更高,并且在吸收剂量形成停止后的很长一段时间内,损伤数量有统计学意义的增加,这表明全身照射的间接效应导致了遗传结构的损伤,并允许大致估计其贡献(高达50%)。

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