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与转录激活因子jun家族相关的四个基因座在小鼠中的遗传定位。

Genetic mapping in the mouse of four loci related to the jun family of transcriptional activators.

作者信息

Shapiro M, Kozak C A

机构信息

Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

出版信息

Somat Cell Mol Genet. 1991 Jul;17(4):341-7. doi: 10.1007/BF01233059.

Abstract

Southern blot analysis of DNAs from somatic cell hybrids and the progeny of an intersubspecies backcross were used to identify and chromosomally map four loci in the mouse containing sequences cross-reactive to members of the jun family of transcriptional activators. The murine homolog of v-jun, Jun, was mapped to chromosome (Chr) 4, and a locus containing jun B-related sequences (Junb) was mapped to Chr 8. Probes for jun D identified two genetic loci; one, Jund-1, is near Junb on Chr 8, and a second, previously unidentified locus termed Jund-2, was mapped to Chr 2.

摘要

利用来自体细胞杂种和亚种间回交后代的DNA进行Southern印迹分析,以鉴定和染色体定位小鼠中四个含有与转录激活因子jun家族成员交叉反应序列的基因座。v-jun的小鼠同源物Jun被定位到4号染色体(Chr),一个含有jun B相关序列(Junb)的基因座被定位到8号染色体。jun D的探针鉴定出两个遗传位点;一个是Jund-1,位于8号染色体上靠近Junb的位置,另一个是之前未鉴定的基因座,称为Jund-2,被定位到2号染色体。

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