Ewins D L, Rossor M N, Butler J, Roques P K, Mullan M J, McGregor A M
Department of Medicine, King's College School of Medicine, London, UK.
Clin Endocrinol (Oxf). 1991 Jul;35(1):93-6. doi: 10.1111/j.1365-2265.1991.tb03502.x.
To determine the prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and to ascertain whether there is any evidence for genetic linkage between the two conditions.
Retrospective study of Familial Alzheimer's Disease kindreds.
Seventy affected and unaffected family members from 12 kindreds.
Anti-thyroglobulin and anti-microsomal autoantibody status was determined using an enzyme-linked immunosorbent assay. Thyrotrophin levels were determined by an immunoradiometric assay.
Of the family members, 41.4% had evidence of autoimmune thyroid disease, with significant co-segregation between the presence of thyroid autoantibodies and the development of Alzheimer's disease (P less than 0.01).
This study demonstrates a very high prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and suggests that a genetic factor contributing towards the development of autoimmune thyroid disease may be located on chromosome 21 within close proximity to the Familial Alzheimer's Disease gene.
确定家族性阿尔茨海默病亲属中自身免疫性甲状腺疾病的患病率，并确定这两种疾病之间是否存在遗传连锁的证据。
对家族性阿尔茨海默病亲属进行回顾性研究。
来自12个家族的70名患病和未患病的家庭成员。
采用酶联免疫吸附测定法测定抗甲状腺球蛋白和抗微粒体自身抗体状态。采用免疫放射测定法测定促甲状腺激素水平。
在家庭成员中，41.4%有自身免疫性甲状腺疾病的证据，甲状腺自身抗体的存在与阿尔茨海默病的发生之间存在显著的共分离现象（P<0.01）。
本研究表明家族性阿尔茨海默病亲属中自身免疫性甲状腺疾病的患病率非常高，并提示促成自身免疫性甲状腺疾病发生的一个遗传因素可能位于21号染色体上，与家族性阿尔茨海默病基因紧密相邻。
