Silman A J, Ollier W E, Bubel M A
Department of Clinical Epidemiology, London Hospital Medical College.
Br J Rheumatol. 1989 Feb;28(1):18-21. doi: 10.1093/rheumatology/28.1.18.
All 504 available members from 58 multicase rheumatoid arthritis (RA) families were interviewed and examined for the presence or history of autoimmune thyroid disease and were tested serologically for thyroid autoantibodies. The serological data were compared with those from a major population survey which used the same assay methods. Overall, 6% had thyroid disease with a fivefold female excess. Thyroglobulin antibodies were present in 5% of males and 11% of females and thyroid microsomal antibodies in 5% of males and 15% of females. These rates were all significantly greater than published rates for the general population. The differences persisted after analysing separately by age group. The results confirm the suggestions by others that there may be a common genetic link between RA and autoimmune thyroid disease.
对来自58个多病例类风湿性关节炎（RA）家庭的所有504名成员进行了访谈，检查他们是否存在自身免疫性甲状腺疾病或病史，并进行甲状腺自身抗体的血清学检测。将血清学数据与使用相同检测方法的一项主要人群调查的数据进行比较。总体而言，6%的人患有甲状腺疾病，女性患病率是男性的五倍。男性中5%、女性中11%存在甲状腺球蛋白抗体，男性中5%、女性中15%存在甲状腺微粒体抗体。这些比率均显著高于一般人群公布的比率。按年龄组分别分析后，差异仍然存在。结果证实了其他人的推测，即RA与自身免疫性甲状腺疾病之间可能存在共同的遗传联系。
