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一名无症状特应性患者急性氯气暴露后发生的慢性反应性气道疾病。

Chronic reactive airway disease following acute chlorine gas exposure in an asymptomatic atopic patient.

作者信息

Moore B B, Sherman M

机构信息

Department of Medicine, Hahnemann University Hospital, Philadelphia.

出版信息

Chest. 1991 Sep;100(3):855-6. doi: 10.1378/chest.100.3.855.

DOI:10.1378/chest.100.3.855
PMID:1889286
Abstract

While chlorine gas inhalation has previously been reported to cause temporary mucous membrane irritation, acute pneumonitis, pulmonary edema, and transient bronchospasm, there is controversy about the existence of long-term pulmonary sequelae. We report the case of a 25-year-old man in whom chronic, recurrent asthma developed after exposure to a chlorine gas leak in an enclosed space. His course since the exposure has been notable for frequent exacerbations necessitating chronic corticosteroid therapy and multiple hospitalizations. To our knowledge, the persistence of symptoms years after the exposure is unique in the literature.

摘要

虽然此前有报道称吸入氯气会导致暂时的粘膜刺激、急性肺炎、肺水肿和短暂的支气管痉挛,但关于长期肺部后遗症的存在仍存在争议。我们报告了一例25岁男性的病例,该患者在封闭空间接触氯气泄漏后患上了慢性复发性哮喘。自接触氯气以来,他的病情以频繁发作、需要长期使用皮质类固醇治疗以及多次住院为特征。据我们所知,接触氯气多年后症状仍持续存在,这在文献中是独一无二的。

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吸入氯气后,对大鼠进行抗氧化治疗可减少气道增生和高反应性。
Am J Respir Cell Mol Biol. 2012 May;46(5):599-606. doi: 10.1165/rcmb.2011-0196OC. Epub 2011 Dec 8.
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Chlorine: state of the art.氯:最新技术水平。
Lung. 2005 May-Jun;183(3):151-67. doi: 10.1007/s00408-004-2530-3.
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Hazardous air pollutants and asthma.有害空气污染物与哮喘。
Environ Health Perspect. 2002 Aug;110 Suppl 4(Suppl 4):505-26. doi: 10.1289/ehp.02110s4505.
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