硫衍生物对T细胞分化的类胸腺活性。
Thymus-like activities of sulphur derivatives on T-cell differentiation.
作者信息
Renoux G, Renoux M
出版信息
J Exp Med. 1977 Feb 1;145(2):466-71. doi: 10.1084/jem.145.2.466.
Abstract
Levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. These sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. In vivo treatment with sulphur derivative can substitute for an alleged thymice hormone.
摘要
左旋咪唑和二乙基二硫代氨基甲酸钠可诱导无胸腺裸鼠脾脏前体细胞在体内分化为胸腺细胞，并在经绵羊红细胞免疫的裸鼠体内引发间接空斑形成细胞。这些含硫药物可在无胸腺小鼠体内诱导产生一种血清因子，该因子可在体内传递免疫增强作用，并在体外诱导胸腺细胞分化。用含硫衍生物进行体内治疗可替代一种所谓的胸腺激素。
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