• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effect of levamisole on autologous rosette-forming cells in nude mice.左旋咪唑对裸鼠自体花环形成细胞的作用。
Clin Exp Immunol. 1977 Dec;30(3):465-8.
2
Comparison of the in vitro effects of thymopoietin pentapeptide and levamisole on peripheral E-rosette forming cells.
Thymus. 1980 Jan;1(4-5):195-204.
3
Pharmacological induced depression of E-rosette forming cells (RFC) of normal healthy subjects. Restoration by levamisole and thymopoietin pentapeptide.药物诱导正常健康受试者E玫瑰花结形成细胞（RFC）减少。左旋咪唑和胸腺生成素五肽可使其恢复。
Boll Soc Ital Biol Sper. 1980 Feb 29;56(4):316-22.
4
[Effect of levamisole on lymphoid cells in vitro].[左旋咪唑对体外淋巴细胞的作用]
Tsitol Genet. 1980 Nov-Dec;14(6):9-13.
5
Functional maturation difference between splenocytes that form autologous rosettes in adult thymectomized and aged mice.
Thymus. 1983;5(1):35-42.
6
In vitro differentiation of two surface markers for immature T cells by the synthetic pentapeptide, thymopoietin.
J Immunol. 1981 Jan;126(1):150-3.
7
Effects of levamisole on spontaneous rosette-forming cells in murine spleen.
Eur J Immunol. 1976 Apr;6(4):305-7. doi: 10.1002/eji.1830060414.
8
[Increase in the content of thymus hormone sensitive rosette-forming cell precursors in the spleen of mice vaccinated against smallpox].
Biull Eksp Biol Med. 1978 Oct;86(10):458-9.
9
Effect of levamisole, thymic humoral factor and indomethacin on e-rosette formation of lymphocytes in Hodgkin's disease.左旋咪唑、胸腺体液因子及消炎痛对霍奇金病淋巴细胞E-玫瑰花结形成的影响
Isr J Med Sci. 1981 Apr;17(4):232-5.
10
The effect of levamisole on E-rosette formation by trypsinized lymphocytes.左旋咪唑对胰蛋白酶处理的淋巴细胞形成E花环的影响。
Clin Exp Immunol. 1978 Sep;33(3):499-502.

本文引用的文献

1
Carbon clearance enhancing factor in serum from levamisole treated mice.
J Reticuloendothel Soc. 1975 Feb;17(2):65-72.
2
Therapeutic trials with levamisole and other agents in NZB/W mice.左旋咪唑及其他药物在新西兰黑/白小鼠中的治疗试验。
J Rheumatol. 1976 Dec;3(4):380-3.
3
Effects of levamisole on spontaneous rosette-forming cells in murine spleen.
Eur J Immunol. 1976 Apr;6(4):305-7. doi: 10.1002/eji.1830060414.
4
Peripheral blood lymphocyte populations in chronic liver disease.慢性肝病中的外周血淋巴细胞群体
Clin Exp Immunol. 1976 Nov;26(2):222-7.
5
The effect of Levamisole on peripheral blood lymphocyte subpopulations in patients with rheumatoid arthritis and ankylosing spondylitis.左旋咪唑对类风湿关节炎和强直性脊柱炎患者外周血淋巴细胞亚群的影响。
Clin Exp Immunol. 1976 Sep;25(3):493-6.
6
Binding of autologous erythrocytes to immature T-cells.自体红细胞与未成熟T细胞的结合。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3201-5. doi: 10.1073/pnas.72.8.3201.
7
The levamisole story.
Prog Drug Res. 1976;20:347-83. doi: 10.1007/978-3-0348-7094-8_11.
8
Potentiation of T-cell mediated immunity by levamisole.左旋咪唑对T细胞介导免疫的增强作用。
Clin Exp Immunol. 1976 Aug;25(2):288-96.
9
Adult thymectomy promotes the manifestation of autoreactive lymphocytes.
Cell Immunol. 1977 Feb;28(2):274-83. doi: 10.1016/0008-8749(77)90111-3.
10
Thymus-like activities of sulphur derivatives on T-cell differentiation.硫衍生物对T细胞分化的类胸腺活性。
J Exp Med. 1977 Feb 1;145(2):466-71. doi: 10.1084/jem.145.2.466.

左旋咪唑对裸鼠自体花环形成细胞的作用。

Effect of levamisole on autologous rosette-forming cells in nude mice.

作者信息

Van Wauwe J, Van Nijen G

出版信息

Clin Exp Immunol. 1977 Dec;30(3):465-8.

PMID:304789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541137/
Abstract

Levamisole depresses the number of autologous rosette-forming cells (ARFC) in the spleen of nude (congenitally athymic) mice. Intravenous administration of 2.5 mg/kg of levamisole produces maximal depression. This effect appears 15 h after injection and is transient, partially disappearing after 48 hr. Dexamisole is devoid of this depressing activity. Thymopoietin, a thymic hormone, is also shown to lower the level of autologous rosette formation. These results suggest a stereospecific interference of levamisole with the maturation of immature T-cell precursors in a manner resembling the action of thymic hormones.

摘要

左旋咪唑可降低裸（先天性无胸腺）鼠脾脏中自体花环形成细胞（ARFC）的数量。静脉注射2.5毫克/千克的左旋咪唑可产生最大程度的抑制作用。这种作用在注射后15小时出现，且是短暂的，48小时后部分消失。地塞米唑没有这种抑制活性。胸腺生成素，一种胸腺激素，也被证明可降低自体花环形成水平。这些结果表明，左旋咪唑以类似于胸腺激素作用的方式对未成熟T细胞前体的成熟进行立体特异性干扰。