Iwase A, Aiba M, Kira S
Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Int Arch Occup Environ Health. 1991;63(2):139-43. doi: 10.1007/BF00379078.
The aim of this study was to measure nicotine concentrations in inspired and expired air so as to learn more about respiratory (nasopharyngeal cavity and lung) nicotine absorption from inspired air and to estimate the nicotine intake during passive smoking. A total of 17 young non-smoking women were exposed to experimental passive smoking. Inspired and expired air was sucked at a constant rate into samplers filled with acid-treated diatomite (Uniport-S) to absorb nicotine in the air. Absorbed nicotine was assayed by gas chromatography. The range of nicotine concentration in the inspired air was 40-200 micrograms/m3. In this setting, 47 samples obtained from the 17 subjects were assayed. Nicotine absorption, which was calculated as [(nicotine concentration in inspired air-nicotine concentration in expired air)/nicotine concentration in inspired air] x 100, remained at 60%-80% (mean +/- SD, 71.3% +/- 10.2%) without being affected by the nicotine concentration in the inspired air. From this result, it was estimated that the average intake of nicotine was 0.026 mg/h in a group of non-smokers exposed in a room containing a nicotine concentration of 100 micrograms/m3, which is equivalent to fairly severe involuntary tobacco smoking. This is the first report on the estimation of respiratory nicotine absorption and nicotine intake during passive smoking based on the direct measurement of nicotine concentrations in both inspired and expired air.
本研究的目的是测量吸入气和呼出气中的尼古丁浓度，以便更多地了解从吸入气中呼吸道（鼻咽腔和肺）对尼古丁的吸收情况，并估计被动吸烟期间的尼古丁摄入量。共有17名年轻不吸烟女性暴露于实验性被动吸烟环境。以恒定速率将吸入气和呼出气吸入装有酸处理硅藻土（Uniport-S）的采样器中，以吸收空气中的尼古丁。通过气相色谱法测定吸收的尼古丁。吸入气中尼古丁浓度范围为40 - 200微克/立方米。在此环境下，对从17名受试者获取的47个样本进行了测定。尼古丁吸收率计算为[（吸入气中尼古丁浓度 - 呼出气中尼古丁浓度）/吸入气中尼古丁浓度]×100，保持在60% - 80%（均值±标准差，71.3%±10.2%），且不受吸入气中尼古丁浓度的影响。根据该结果，估计在尼古丁浓度为100微克/立方米的房间中暴露的一组不吸烟者，尼古丁平均摄入量为0.026毫克/小时，这相当于相当严重的非自愿吸烟情况。这是基于对吸入气和呼出气中尼古丁浓度的直接测量来估计被动吸烟期间呼吸道尼古丁吸收和尼古丁摄入量的首份报告。
