日本肺炎衣原体TWAR抗体的流行情况。
Prevalence of antibody to Chlamydia pneumoniae TWAR in japan.
作者信息
Kanamoto Y, Ouchi K, Mizui M, Ushio M, Usui T
机构信息
Division of Microbiology, Hiroshima Prefectural Institute of Public Health, Ujinakanda, Japan.
出版信息
J Clin Microbiol. 1991 Apr;29(4):816-8. doi: 10.1128/jcm.29.4.816-818.1991.
Chlamydia pneumoniae TWAR is a newly recognized Chlamydia species that is a pathogen of respiratory tract infection. To clarify the endemic status of C. pneumoniae in Japan, we evaluated the incidence of C. pneumoniae antibody in 1,330 serum samples (660 from outpatients, 600 from normal individuals, and 70 from cord blood). The antibody titer was determined by a microimmunofluorescence test by using the elementary body of C. pneumoniae TW-183 as the antigen. Immunoglobulin G antibody titers of 1:32 or higher were regarded as evidence of past infection. The detection rate of C. pneumoniae antibody rapidly increased in subjects between the ages of 4 and 7 years, reached 44% in subjects between the ages of 8 and 11 years, and was about 50% in older subjects. The rate did not differ between healthy subjects and outpatients. These results suggest that C. pneumoniae infection is highly endemic in Japan as it is in Western countries. However, the antibody prevalence was high in the low age groups in Japan compared with that in Western countries.
肺炎衣原体TWAR是一种新发现的衣原体菌种，是呼吸道感染的病原体。为了阐明肺炎衣原体在日本的流行状况，我们评估了1330份血清样本（660份来自门诊患者，600份来自正常个体，70份来自脐带血）中肺炎衣原体抗体的发生率。抗体滴度通过微量免疫荧光试验测定，以肺炎衣原体TW-183的原体作为抗原。免疫球蛋白G抗体滴度为1:32或更高被视为既往感染的证据。肺炎衣原体抗体的检出率在4至7岁的受试者中迅速上升，在8至11岁的受试者中达到44%，在年龄较大的受试者中约为50%。健康受试者和门诊患者之间的检出率没有差异。这些结果表明，与西方国家一样，肺炎衣原体感染在日本高度流行。然而，与西方国家相比，日本低年龄组的抗体流行率较高。
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