Katoh-Semba R, Semba R, Kashiwamata S, Kato K
Department of Perinatology, Institute for Developmental Research, Aichi, Japan.
Mech Ageing Dev. 1991 Jun 14;59(1-2):163-75. doi: 10.1016/0047-6374(91)90082-b.
Levels of the beta-subunit of nerve growth factor (beta-NGF) were determined in various tissues from senescence-accelerated mice (SAM-P/8) and compared with those from senescence-resistant control mice (SAM-R/1) at 4 months of age. (1) In SAM-P/8, the testis was 30% larger in terms of wet weight than that from SAM-R/1, whereas the adrenal glands from males and females were smaller than those from the respective controls by 45% and 20%, respectively. (2) About 70% of SAM-P/8 individuals had high concentrations of testosterone in serum (greater than 5ng/ml). (3) In SAM-P/8, endogenous levels of beta-NGF were significantly higher in the adrenal gland (20 and 7 times higher on average in males and females, respectively), in the thymus (100 and 5 times higher in males and females, respectively) and in the testis (500 times higher) than those in the control tissues. In other tissues there were little or no differences in terms of levels of beta-NGF. (4) Morphological changes in the adrenal gland, thymus and testis of SAM-P/8 mice were not as marked as expected from the elevated levels of beta-NGF in these tissues. (5) These results show that, in SAM-P/8 mice at 4 months of age, an elevation in the endogenous level of beta-NGF has already occurred in some peripheral tissues before senescence becomes accelerated.
测定了衰老加速小鼠（SAM-P/8）不同组织中神经生长因子β亚基（β-NGF）的水平，并与4月龄的抗衰老对照小鼠（SAM-R/1）的相应组织水平进行了比较。（1）在SAM-P/8中，睾丸湿重比SAM-R/1的大30%，而雄性和雌性的肾上腺分别比各自对照组的小45%和20%。（2）约70%的SAM-P/8个体血清睾酮浓度较高（大于5ng/ml）。（3）在SAM-P/8中，肾上腺（雄性和雌性平均分别高20倍和7倍）、胸腺（雄性和雌性分别高100倍和5倍）和睾丸（高500倍）中的β-NGF内源性水平显著高于对照组织。在其他组织中，β-NGF水平几乎没有差异。（4）SAM-P/8小鼠肾上腺、胸腺和睾丸的形态学变化并不像这些组织中β-NGF水平升高所预期的那样明显。（5）这些结果表明，在4月龄的SAM-P/8小鼠中，在衰老加速之前，一些外周组织中β-NGF的内源性水平已经升高。
