Letić-Gavrilović A, Colić M, Okina A, Shibaike S, Abe K
Shika Kiso Igakkai Zasshi. 1989 Aug;31(4):427-35. doi: 10.2330/joralbiosci1965.31.427.
Morphological changes of the T cell immune system compartments (thymus and spleen) and the steroid hormone producing glands (adrenal and testis) in the submandibular-ectomized (SMx) male mice of CBA/H strain were analyzed. Thymus, spleen, testis and adrenal gland were weighed and processed for the morphological examination by light- and electron-microscopy. The serum level of testosterone was evaluated by radioimmunoassay. No weight and morphological changes were observed in the testis and adrenal gland, and the testosterone level in sera was not changed after SMx. These results indicate that any relationship between the submandibular salivary glands and the immune system was not mediated through them. The epithelial hormone-producing cells located in thymus medulla showed the most prominent changes after SMx evaluated by the neuron specific enolase immunostainings and by the ultrastructural analysis. After SMx, the number of very active epithelial hormone-producing cells in both cortex and medulla of the thymus was markedly increased.
对CBA/H品系的雄性小鼠进行下颌下腺切除（SMx）后，分析其T细胞免疫系统区室（胸腺和脾脏）以及产生类固醇激素的腺体（肾上腺和睾丸）的形态变化。称取胸腺、脾脏、睾丸和肾上腺的重量，并通过光学显微镜和电子显微镜进行形态学检查。通过放射免疫测定法评估血清睾酮水平。在睾丸和肾上腺中未观察到重量和形态变化，SMx后血清中的睾酮水平也未改变。这些结果表明，下颌下唾液腺与免疫系统之间的任何关系都不是通过它们介导的。通过神经元特异性烯醇化酶免疫染色和超微结构分析评估，位于胸腺髓质的上皮激素产生细胞在SMx后显示出最显著的变化。SMx后，胸腺皮质和髓质中非常活跃的上皮激素产生细胞数量明显增加。
