Kurisu H, Kamisaka K, Koyo T, Yamasuge S, Igarashi H, Maezawa H, Uesugi T, Tagaya O
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Life Sci. 1991;49(14):1003-11. doi: 10.1016/0024-3205(91)90301-q.
The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities.
EHBR是一种从斯普拉格-道利大鼠培育而来的患有先天性结合胆红素血症的突变大鼠品系。这些大鼠中，结合胆红素、吲哚菁绿和四溴酚酞磺酸钠从肝脏到胆汁的转运严重受损。成年大鼠血清胆红素含量为6.0±0.05mg/dl（n = 4），其中97%为结合物。胆汁流量降至对照组的约65%，而10分钟胆汁样本中的总胆汁酸含量相似。10周龄大鼠的肝脏组织学检查未发现细胞内色素沉着或结构异常。
