Kaplan M H, Hall W W, Susin M, Pahwa S, Salahuddin S Z, Heilman C, Fetten J, Coronesi M, Farber B F, Smith S
Department of Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030.
Am J Med. 1991 Sep;91(3):300-9. doi: 10.1016/0002-9343(91)90132-h.
Two intravenous drug users dually infected with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type II (HTLV-II) developed an unusual severe dermatitis characterized by progressive brawny induration, fissuring, and ulceration of the skin, with an associated CD8 cell infiltration in one patient. Both patients had persistent eosinophilia. Lymph node biopsy revealed dermatopathic lymphadenopathy, an unusual pathologic finding in HIV-1 infection but one seen in association with mycosis fungoides and other skin disorders. Two new isolates of HTLV-II virus were established from these patients and were identified as HTLV-II by Southern blotting. This type of skin disease and lymph node pathology has not been found in other intravenous drug users who have been infected with HIV-1 alone or in patients in other risk groups for HIV-1 infection. HTLV-II may play a role in this unique new disease pattern in patients infected with HIV-1.
两名同时感染1型人类免疫缺陷病毒（HIV-1）和II型人类T细胞白血病病毒（HTLV-II）的静脉吸毒者患上了一种罕见的严重皮炎，其特征为皮肤进行性硬结、皲裂和溃疡，其中一名患者伴有CD8细胞浸润。两名患者均持续嗜酸性粒细胞增多。淋巴结活检显示为皮肤淋巴细胞瘤，这在HIV-1感染中是一种不寻常的病理发现，但在蕈样肉芽肿和其他皮肤疾病中可见。从这些患者中分离出两株新的HTLV-II病毒株，并通过Southern印迹法鉴定为HTLV-II。在仅感染HIV-1的其他静脉吸毒者或其他HIV-1感染风险组的患者中未发现这种类型的皮肤疾病和淋巴结病理。HTLV-II可能在感染HIV-1的患者的这种独特新疾病模式中起作用。
