红色假交替单胞菌中的一种 2-取代普洛托京，2-(对羟基苄基)普洛托青。
A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra.
机构信息
Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA.
出版信息
J Nat Prod. 2008 Nov;71(11):1970-2. doi: 10.1021/np800493p. Epub 2008 Oct 15.
Abstract
In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2-substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).
摘要
在从海洋细菌中发现新的药物先导化合物的工作过程中，一种红色假交替单胞菌的亲脂提取物对 SKOV-3（人卵巢腺癌细胞系）表现出显著的细胞毒性。对该提取物进行生物活性导向的分段分离，得到了一系列已知和新的变形菌红素型氮杂富烯。主要代谢产物的结构通过光谱数据分析阐明为 2-取代的灵菌红素，我们将其命名为 2-(对羟基苄基)灵菌红素（HBPG）。
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