Department of Medicine, McMaster University.
Can J Infect Dis Med Microbiol. 2007 Mar;18(2):149-50. doi: 10.1155/2007/768734.
There has been a gradual increase in the incidence of non-Candida albicans-related nosocomial infections. Candida glabrata urinary tract infections have increased in frequency, and treating these infections can be difficult because the organism may be resistant to fluconazole. A newer antifungal agent, micafungin, which belongs in the class of echinocandins, provides an alternative and effective therapy against C glabrata. The present report describes three cases of C glabrata-associated urinary tract infections successfully treated with micafungin. To the authors' knowledge, this is the first report of successful treatment of C glabrata and azole-resistant C albicans-associated urinary tract infection with an echinocandin.
非白念珠菌相关医院感染的发病率逐渐上升。光滑念珠菌尿路感染的发病率也有所增加，而且由于该病原体可能对氟康唑耐药，治疗这些感染可能具有挑战性。新型抗真菌药物米卡芬净属于棘白菌素类，为治疗光滑念珠菌提供了一种替代且有效的治疗方法。本报告描述了三例成功用米卡芬净治疗的光滑念珠菌相关尿路感染。据作者所知，这是首例成功用棘白菌素治疗光滑念珠菌和唑类耐药白念珠菌相关尿路感染的报告。
