Fukuda H, Imayama S, Okada K
Fukuda Dermatological Clinic.
Arerugi. 1991 Jun;40(6):626-32.
While there are increasing data supporting the view that mite allergen sensitivity is one of the major causes of atopic dermatitis (AD) as well as asthma, it is practically difficult to avoid house dust allergens as part of the management of AD. Therefore, we served a conditioned room in which mites were eliminated to the level less than 3 mites/m2, named mite free room (MFR) for experimental treatment of AD to evaluate the possible therapeutic effect of the mite-free condition. Thirteen relatively severe patients with high-IgE RAST score to the mite allergens were treated with night time admission to the MFR without disturbing their social activities in the day time. Our MFR treatment gave eleven of the thirteen patients relief from itch and dermatitis within 2 to 3 weeks, yet they stayed average only 11 hours a day in the MFR. These results may provide a possible candidate in the treatment of AD instead of topical and/or systemic medicines of which prolonged usage is sometimes associated with adverse side effects.
虽然越来越多的数据支持螨过敏原敏感性是特应性皮炎（AD）以及哮喘的主要病因之一的观点，但在AD的管理中，实际上很难避免屋尘过敏原。因此，我们提供了一个经过处理的房间，将螨虫数量减少到每平方米少于3只，命名为无螨房间（MFR），用于AD的实验性治疗，以评估无螨环境可能的治疗效果。对螨过敏原RAST评分高的13例相对严重的患者，在不干扰其白天社交活动的情况下，夜间入住MFR进行治疗。我们的MFR治疗使13例患者中的11例在2至3周内瘙痒和皮炎得到缓解，但他们平均每天仅在MFR中停留11小时。这些结果可能为AD的治疗提供一种可能的选择，以替代有时长期使用会伴有不良副作用的局部和/或全身药物。
