Andrade Flávia R, Sousa Débora P, Mendonça Elismauro F, Silva Tarcília A, Lara Vanessa S, Batista Aline C
Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Oct;106(4):548-55. doi: 10.1016/j.tripleo.2008.05.042.
To investigate the expression of bone resorption regulators (receptor activator of nuclear factor kappa B [RANK], RANK ligand [RANKL], and osteoprotegerin [OPG]) in calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), odontogenic myxoma (OM), and ameloblastic fibroma (AF).
The expression of these mediators was evaluated by means of immunohistochemistry.
All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG.
Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption.
研究骨吸收调节因子（核因子κB受体激活剂[RANK]、RANK配体[RANKL]和骨保护素[OPG]）在钙化囊性牙源性肿瘤（CCOT）、腺样牙源性肿瘤（AOT）、钙化上皮性牙源性肿瘤（CEOT）、牙源性黏液瘤（OM）和成釉细胞纤维瘤（AF）中的表达。
通过免疫组织化学评估这些介质的表达。
所有标本对RANK、RANKL和OPG均显示阳性免疫反应。这些介质在上皮中的定量分析显示，CCOT、AOT、CEOT和AF中RANKL和OPG的表达模式相似。关于基质/间充质细胞，大多数AOT和CCOT病例显示OPG含量高于RANKL，而CEOT、OM，尤其是AF倾向于呈现RANKL含量高于OPG。
我们的数据表明，CCOT、AOT、CEOT、OM和AF细胞成分表达骨代谢的关键调节因子，可能在局部调节肿瘤相关骨吸收。
