来自佛罗里达软珊瑚的具有细胞毒性的异西加烷型二萜类化合物。

Xenicane-type diterpenes with cytotoxicity from Xenia florida.

作者信息

Cheng Yuan-Bin, Jang Jiun-Yang, Khalil Ashraf Taha, Kuo Yao-Haur, Shen Ya-Ching

机构信息

Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.

出版信息

J Nat Prod. 2006 Apr;69(4):675-8. doi: 10.1021/np058110c.

DOI:10.1021/np058110c

PMID:16643051

Abstract

Chromatographic investigation of an acetone extract of the octocoral Xenia florida afforded three new xenicane diterpenes, namely, florxenilide A (1), florxenilide B (2), and florxenilide C (3), in addition to seven known xenicane diterpenes and two known cadinene sesquiterpenes. Structures were elucidated through spectroscopic analysis, especially 2D NMR, and chemical derivatization. The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A (1) and B (2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 muM, respectively.

摘要

对八放珊瑚佛罗里达软珊瑚（Xenia florida）的丙酮提取物进行色谱分析，除得到七种已知的异海松烷二萜和两种已知的杜松烯倍半萜外，还得到了三种新的异海松烷二萜，即佛罗里达软珊瑚酰胺A（1）、佛罗里达软珊瑚酰胺B（2）和佛罗里达软珊瑚酰胺C（3）。通过光谱分析，尤其是二维核磁共振（2D NMR）和化学衍生化确定了其结构。通过核Overhauser效应光谱（NOESY）、圆二色光谱（CD）和莫舍尔法确定了1的绝对构型。佛罗里达软珊瑚酰胺A（1）和B（2）分别在4.5和3.7 μM浓度下对人结肠癌细胞（WiDr）表现出细胞毒性。